Clarice Starling (Jodie Foster), who is continuing her education at the FBI, enters a high-security madhouse and tries to go deep into the sick mind of Hannibal Lecter (Anthony Hopkins), who turned into a mass murderer who was a cannibalist while he was a psychiatrist. Starling needs tips to catch a serial killer. Unfortunately, the Faustian relationship she had with Lecter eventually led to his escape and two separate serial killers will roam freely in the dark.